Synthesis and Characterisation of Some Mixed ArtemisininNicotinamide and Artemisinin-Ascorbic Acid: Metal Complexes and their Antimicrobial Activity Studies

Abstract

Metal complexes of Zn2+, Mn2+, Cu2+ and Fe3+ with mixed artemisinin-nicotinamide and artemisinin-ascorbic acid have been synthesized and characterized using infrared and electronic spectroscopic analysis, melting point determination and conductivity measurements. The two ligands have been found to act as bidentate chelating agents with artemisinin-nicotinamide coordinating through the carbonyl and amide groups, while artemisinin-ascorbic acid coordinated through the hydroxyl and carbonyl groups. Antibacterial screening of the complexes against five bacteria- Escherichia coli, Staphylococcus aureus, Klebsiella pneumonia, Pseudomonas aureginosa and Proteus mirabilis, was also investigated. The metal complexes were found to have varied degree of inhibitory effect against the bacteria.